Graseby 3300 PCA pump

Misprogram a PCA Pump? It's Easy!

Vol. 33 No. 10 • October 2008 • P&T® 567 programmed the bolus dose, but because the pump had been set incorrectly at a 1-mcg/mL of the 50-mcg/mL concentration, or 1,000 mcg! About 15 minutes later, the patient was found to be unresponsive and was quickly transferred to the intensive-care unit. The patient died three days later. In this fatal event, the two nurses had been familiar with fentanyl...

Model-Based Development of the Generic PCA Infusion Pump User Interface Prototype in PVS

A realistic user interface is rigorously developed for the US Food and Drug Administration (FDA) Generic Patient Controlled Analgesia (GPCA) pump prototype. The GPCA pump prototype is intended as a realistic workbench for trialling development methods and techniques for improving the safety of such devices. A model-based approach based on the use of formal methods is illustrated and implemented...

EM Algorithms for PCA and Sensible PCA

Smart PCA

PCA can be smarter and makes more sensible projections. In this paper, we propose smart PCA, an extension to standard PCA to regularize and incorporate external knowledge into model estimation. Based on the probabilistic interpretation of PCA, the inverse Wishart distribution can be used as the informative conjugate prior for the population covariance, and useful knowledge is carried by the pri...

Circular PCA

Experimental time courses often reveal a nonlinear behaviour. Analysing these nonlinearities is even more challenging when the observed phenomenon is cyclic or oscillatory. This means, in general, that the data describe a circular trajectory which is caused by periodic gene regulation. Nonlinear PCA (NLPCA) is used to approximate this trajectory by a curve referred to as nonlinear component. Wh...